The muscle areas obtained by the two software programs were comparable, showing high correlation with Lin’s concordance coefficient (0.9997 95% confidence intervals: 0.9995–0.9999) and very good agreement with Bland–Altman analysis (mean difference = 0.41 cm 2, lower limit = −1.06 cm 2, upper limit = 1.89) was also found. In this study, we compared two semiautomatic freeware software tools (Horos Medical Image software and LIFEx) for the assessment of coronary artery calcium (CAC) score and muscle mass in 40 patients undergoing whole-body PET/CT. The use of freeware software is promising for quantitative evaluation of these parameters after whole-body positron emission tomography (PET)/computed tomography (CT) and might be useful for one-stop shop risk stratification without additional radiation ionizing burden and further charges to health care costs. Coronary artery calcification and sarcopenia may have a relevant prognostic impact in oncological and non-oncological patients.
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